Economic aspects of treatment with captopril after MI.
نویسندگان
چکیده
associated with increased mortality in the setting of incessant tachycardia'. This was also the experience of more recent investigators using surgery. Other investigational approaches never fulfilled their initial promise'". Therefore, the work of Cao and Gonska is very important. It confirms earlier reports on sustained ventricular tachycardia, and proves not only that it is possible to localize the area of slow conduction and interrupt re-entry in patients with ischaemic heart disease (and possibly with large aneurysms), but also that this can be achieved very successfully in critically ill patients; the complication rate is surprisingly low. The fact that there are recurrences of tachycardia during the follow-up is no surprise, but as implantable cardioverters/ defibrillators are available these situations can be managed. These results are so encouraging that a more aggressive approach may be possible — also as regards paroxysmal sustained tachycardia — before proceeding to the implantation of devices. Briefly, the paper by Cao and Gonska is the herald of more work in the cath lab in the foreseeable future.
منابع مشابه
Early captopril treatment inhibits DNA synthesis in endothelial cells and normalization of maximal coronary flow in infarcted rat hearts.
OBJECTIVES Cardiac remodeling due to myocardial infarction (MI) includes myocyte hypertrophy, collagen deposition, a rise in DNA synthesis, and normalization of initially diminished maximal coronary bloodflow. Previously, we demonstrated that early captopril treatment can prevent the rise in total DNA synthesis, collagen deposition and hypertrophy. In the present experiments, we investigated th...
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OBJECTIVES The contribution of vascular changes to the development of heart failure is largely unknown. In the present study, we evaluated endothelial and vascular contractile function in the rat hindlimb vascular bed after myocardial infarction (MI), including the modulatory role of basal nitric oxide (NO) production and the effects of treatment with the angiotensin converting enzyme inhibitor...
متن کاملEffects of angiotensin converting enzyme inhibition on cardiac innervation and ventricular arrhythmias after myocardial infarction.
PURPOSE To investigate the influence of angiotensin-converting enzyme inhibitor (ACEI) on cardiac innervation and inducible ventricular arrhythmias (VAs) in healed myocardial infarction (MI). METHODS Left anterior descending coronary artery was ligated to induce MI in 30 rabbits. After oral captopril (10mg/kg/d) for 8 weeks, electrophysiological study was performed to evaluate the incidence o...
متن کاملChanges in ventricular size and function in patients treated with valsartan, captopril, or both after myocardial infarction.
BACKGROUND Angiotensin-converting enzyme (ACE) inhibitors have been shown to attenuate left ventricular (LV) enlargement in association with reducing mortality after myocardial infarction (MI). Preclinical data suggest that angiotensin receptor blockers (ARBs) may have similar structural and functional effects after MI. The Valsartan in Acute Myocardial Infarction (VALIANT) Echo study was desig...
متن کاملEffects of early angiotensin-converting enzyme inhibition on cardiac gene expression after acute myocardial infarction.
BACKGROUND ACE inhibition after myocardial infarction (MI) has been shown to have beneficial effects on cardiac anatomy and function. The purpose of this study was to examine the effects of ACE inhibition on cardiac gene expression after MI. METHODS AND RESULTS Rats were randomized to receive captopril or no treatment 1 day after MI. Eight weeks later, cardiac function and hemodynamics were m...
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عنوان ژورنال:
- European heart journal
دوره 17 5 شماره
صفحات -
تاریخ انتشار 1996